Methods for strategically leveraging standard of care therapies
Given that the standard of care (surgery, chemotherapy, radiation, immunotherapy, hormone ablatement therapy) is well understood to be effective for managing tumor burden in the near term, but comparatively ineffective for contributing meaningfully to Overall Survivorship, as evidenced by the fact that data from the American Cancer Society reveals that the number of people dying in the US from cancer in 2013 was 580,350, and in 2020 it was 606,520, an increase of 4.3%, while the US population increase over this same period was 4.5%, demonstrates that no substantive and material progress in cancer management has transpired in the modern epoch. Notably, cancer is predicted to overtake heart disease as the leading cause of death in Western societies.
With these limitations in mind, how can one strategically include elements of the standard of care, in context to the Press/Pulse protocol?
Firstly, it’s important to grasp there are no models of cancer that retain aggressive and limitless replicative capacity in the simultaneous downregulation (let alone absence) of glycolysis and glutaminolysis, despite substitution with non-fermentable fuels such as ketone bodies, fatty acids, pyruvate, and lactate. Similarly, neither basic nor clinical research to date supports the notion that tumors with certain mutations, such as BRAF or V600E, can effectively ferment fatty acids or ketone bodies at all, in order to maintain constant growth after effective dual targeting of glucose and glutamine.
With this understanding in hand, one can begin to discern the advantages that come with using Press/Pulse protocol to potentiate the disease management impact of chemotherapy and radiation, enhancing their effects, and mitigating their side effects.
For example, using glucose and ketone control to mediate inflammatory oncotaxis and acidification of the tumor microenvironment prior to surgery, can offer a means of potentiating the effects of surgical debulking, by virtue of downregulating lesion size, thereby offering an opportunity to produce more optimal resection margins.
Correspondently, wrapping Hyperbaric Oxygen Therapy around radiation treatments can downregulate the most egregious side effects of ionizing radiation, while enhancing its efficacy via hyper oxygenation of the tumor microenvironment.
Additionally, combining control of glycolysis and glutaminolysis in the presence of lower doses of chemotherapy can make cytotoxic poisons less harmful to off target tissues, and more damaging to tumor tissue.
Hence, utilizing Press/Pulse protocol alongside a judicious selection of standard of care therapies, can constitute a sustainable and low toxicity method for managing disease, over time.